Process for manufacture of trans-(r,r)-actinol

Details Process for manufacture of trans-(r,r)-actinol Process for manufacture of trans-(r,r)-actinol

C - Chemistry, Metallurgy

07

C

C07C 49/497 (2006.01) B01J 31/18 (2006.01) B01J 31/22 (2006.01) C07C 45/61 (2006.01) C07C 45/64 (2006.01) C07F 15/00 (2006.01)

Patent

CA 2253888

A process for the manufacture of trans-(R,R)-actinol by diasteroselective transfer hydrogenation of levodione comprises hydrogenating (R)-levodione in the presence of a hydrogen donor, which simultaneously can be used as the solvent, and an amino-amide--ruthenium complex, especially of the formula RuH(L{-H})(Y), wherein Y signifies a neutral ligand and L signifies an optionally optically active monosulphonylated diamine ligand, as defined in more detail in the description. Moreover, the invention is concerned with some of the amino-amide-ruthenium complexes and with the corresponding precursors to these complexes, which have halogen in place of H. The product of the process in accordance with the invention, trans-(R,R)--actinol, is known as an important building block for the synthesis of carotenoids, e.g. zeaxanthin. By the process trans-(R,R)-actinol is made available in particularly high enantiomeric and diasteromeric purity.

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