Process for manufacturing...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 215/26 (2006.01) A61K 31/4704 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2752246

A process for preparing the compound of formula (I), or a Pharmaceutically acceptable salt thereof, (I) which process comprises: reacting, in a xylene solvent, a compound of formula (V) with the compound of formula (IV) to give a compound of formula (III) followed by a P1 deprotection step and a P2 deprotection step.

La présente invention concerne un procédé de fabrication de la 5-(2-{[6-(2,2-difluoro-2-phényléthoxy)hexyl]-amino}-L-hydroxyéthyl)-8-hydroxyquinolin-2(1H)-one. L'invention concerne également un procédé de préparation du composé de formule (I), ou un sel pharmaceutiquement acceptable de celui-ci, (I) le procédé comprenant les étapes consistant à : faire réagir, dans un solvant xylène, un composé de formule (V) avec le composé de formule (IV), afin d'obtenir un composé de formule (III), suivie d'une étape de déprotection P1 et d'une étape de déprotection P2.

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