Process for manufacturing d camphorate of l carnitinamide...

C - Chemistry – Metallurgy – 07 – C

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260/555.7, 260/5

C07C 61/06 (2006.01) C07C 103/183 (1980.01)

Patent

CA 1117977

Process for manufacturing D camphorate of L carnitinamide and D camphorate of D carnitinamide ABSTRACT OF THE DISCLOSURE: A process for manufacturing the D camphorate of L carnitinamide and the D camphorate of D carnitinamide is disclosed, wherein D,L carnitinamide hydrochloride is converted to D,L carnitinamide free base which directly reacts with D camphoric acid either as an aqueous suspension or in solid form, thus obtaining a solution of D camphorate of D,L carnitin- amide. The resolution of the optical isomers is achieved by drying this solution and taking up the residue with isopropanol, whereupon the D camphorate of L carnitinamide crystallizes out of the isopropanol solution and the D camphorate of n carnitin- amide remains in solution.

331403

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