Process for manufacturing low molecular weight heparins by...

Details Process for manufacturing low molecular weight heparins by... Process for manufacturing low molecular weight heparins by...

C - Chemistry, Metallurgy

08

B

260/226

C08B 37/10 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1195322

PROCESS FOR MANUFACTURING LOW MOLECULAR WEIGHT HEPARINS BY DEPOLYMERIZATION OF NORMAL HEPARIN ABSTRACT Process for manufacturing low molecular weight heparin fractions from normal heparin wherein such fractions have better pharmacological and therapeutic properties than the normal heparin. The process comprises the steps of, (a) acififying normal heparin to obtain heparinic acid with a pH in the range of about 3 to about 5, and (b) depolymerizing the heparinic acid by heating in the presence of an oxidizing agent to obtain low molecular weight heparin fractions in the range of about 4,000 Dalton to about 12,000 Dalton.

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