Process for manufacturing n-acyl derivatives of glycines...

Details Process for manufacturing n-acyl derivatives of glycines... Process for manufacturing n-acyl derivatives of glycines...

C - Chemistry, Metallurgy

07

C

260/329, 260/515

C07C 233/45 (2006.01)

Patent

CA 1066305

ABSTRACT OF THE DISCLOSURE This is an improved process of manu- facturing N-acyl derivatives of glycines ?-substituted by radicals with an aromatic nature by condensation of the addition product of glyoxylic acid and an amide, with an aromatic compound. In a first stage, the reaction is carried out at low temperature, in a concentrated sulfuric medium, of an aliphatic nitrile of the formula R-C?N in which R is a radical selected from the group of substituted and unsubsti- tuted, saturated and unsaturated alkyl radicals, with a con- centrated aqueous solution of glyoxylic acid. Then in a second stage, the mixture obtained is condensed also at low temperature with a compound of aromatic nature not inclu- ding a hydroxyl group and having at least one substitutable free hydrogen, and the resulting product is collected. The concentrated sulfuric acid may be supplemented with acetic acid during the second stage. A surface active agent may be also added in this stage. The products are valuable inter- mediates for the preparation of semi-synthetic penicillins.

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