Process for manufacturing ophthalmic suspensions

Details Process for manufacturing ophthalmic suspensions Process for manufacturing ophthalmic suspensions

A - Human Necessities

61

K

A61K 31/54 (2006.01) A61K 9/00 (2006.01) A61K 31/542 (2006.01) A61K 31/77 (2006.01)

Patent

CA 2274680

Ophthalmic suspensions containing brinzolamide or brinzolamide and a beta- blocker and processes for manufacturing the suspensions are disclosed. The use of Tyloxapol or Triton X-100 avoids chrystallization of brinzolamide after autoclaving.

La présente invention concerne d'une part des suspensions ophtalmiques contenant du brinzolamide seul ou du brinzolamide accompagné d'un béta-bloquant, et d'autre part des procédés de fabrication de ces suspensions. L'utilisation de tyloxapol ou de Triton X 100 permet d'éviter la cristallisation du brinzolamide après le passage à l'autoclave.

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