Process for modifying ribosome-inactivating glycoproteins by...

Details Process for modifying ribosome-inactivating glycoproteins by... Process for modifying ribosome-inactivating glycoproteins by...

C - Chemistry, Metallurgy

07

K

167/129

C07K 14/415 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1276108

entitled : PROCESS FOR MODIFYING RIBOSOME-INACTIVATING GLYCOPROTEINS BY OXIDATION OF THEIR OSIDIC UNITS AND FORMATION OF A SCHTFF'S BASE. ABSTRACT OF THE DISCLOSURE Glycoprotein (GPIR) having the ribosome-inhibiting activity of the native GPIR and having a prolonged-action in vivo which is obtained by oxidation of its osidic units by the action of periodate ions, and simultaneous blocking of the oxidation product by formation of a Schiff's base with a suitable primary amine. Said modified glycoprotein may be coupled to an antibody or a fragment thereof in order to form an immunotoxin having a prolonged-action in vivo.

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