Process for n-desmethylating erythromycins and derivatives...

Details Process for n-desmethylating erythromycins and derivatives... Process for n-desmethylating erythromycins and derivatives...

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2309255

Disclosed is an improved and efficient process for N-desmethylating the 3'- amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9- anhydro-erythromycin 6,9-hemiketals.

L'invention concerne un procédé amélioré et efficace pour la N-desméthylation du 3'-amino azote dans les érythromycines, et pour la conversion des érythromycines 3'-N-desméthylées en dérivés 3'-N-substitués de 8,9-anhydro-érythromycine 6,9 hémicétals.

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