Process for natamycin recovery

Details Process for natamycin recovery Process for natamycin recovery

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2186259

A new process for recovering high purity natamycin from fermentation broth containing natamycin comprises the steps of adjusting the pH of the broth to above about 10 and adding an amount of a water-miscible solvent, such as isopropanol, sufficient to dissolve the natamycin in the broth, followed by removing insoluble solids from the pH-adjusted broth, followed by lowering the pH of the broth to a level sufficient to precipitate the natamycin, and removing the natamycin from the broth.

Un nouveau procédé permet de récupérer de la natamycine à haute pureté à partir d'un bouillon de fermentation en contenant. Il consiste à ajuster le pH de ce bouillon au-dessus d'environ 10, à ajouter une quantité d'un solvant miscible avec l'eau, tel que de l'isopropanol, suffisante pour dissoudre la natamycine présente dans ce bouillon, à retirer les particules solides insolubles de ce bouillon à pH ajusté, à abaisser le pH du bouillon à un niveau suffisant pour précipiter la natamycine, et à retirer la natamycine de ce bouillon.

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