C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/3.08, 530/15
C07K 1/113 (2006.01) C07K 14/535 (2006.01)
Patent
CA 1338874
A process for the preparation of a spatial form, which has biological activity, of a protein from a biologically inactive spatial form is described and comprises the pro- tein being dissolved with the addition of a denaturing agent and thus converted into the random coil form, and the solution being allowed to pass through a material which has molecular sieve properties and contains a liquid medium in which the protein can assume a spatial form which has biological activity, and this material having molecu- lar sieve properties being selected so that the molecules of the denaturing agent can penetrate, but the protein molecules cannot. It is possible by centrifugation, blowing or sucking out to remove the medium in the "external-volume" of the molecu- lar sieve and to increase the rate of passage of the solution through the molecular sieve.
538713
Behringwerke Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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