C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
195/1.12
C07H 1/08 (2006.01) C07H 21/04 (2006.01) C12N 15/10 (2006.01)
Patent
CA 1297430
-1- "A process for obtaining chemically defined and reproducible polydeoxyribonucleotides" ABSTRACT By carrying out the depolymerization of stabilized solutions of highly polymerized and nicked polydeoxyribonucleotides, as obtained through stabilizing aggregation of raw nucleic acids, the depolymerization being carried out by heating at controlled temperature and being controlled as a function of the variation of the reversible hyperchromicity, followed by the removal of the hydrogen bonds in the double stranded filaments and by thermal stabilization of the single stranded filaments, the polydeoxy- ribonucleotide, known as Defibrotide is obtained. Defibrotide has the following formula of random sequence: P1-5,(dAp)12-24, (dGp)10-20, (dTp)13-26, (dCp)10-20, wherein P-phosphoric radical dAp= deoxyadenylic monomer dGp= deoxyguanylic monomer dTp= deoxythymidylic monomer dCp= deoxycytidylic monomer and has well defined chemico-physical properties, reproducible in the in- dustrial production.
534837
Diamantini Giuseppe
Fedeli Gianfranco
Mantovani Marisa
Prino Giuseppe
Gentium S.p.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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