C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/06 (2006.01) C07K 1/113 (2006.01) C07K 1/22 (2006.01) C07K 14/62 (2006.01)
Patent
CA 2142780
A process for obtaining insulin having correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan, chaotropic auxiliaries and at a pH of 10 to 11 is described, as well as the direct conversion of the proinsulin to insulin with the aid of enzymes and direct isolation of the insulin from the reaction mixture with the aid of hydrophobic adsorber resins.
Gerl Martin
Ludwig Jurgen
Obermeier Rainer
Sabel Walter
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
Sanofi-Aventis Deutschland Gmbh
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