C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.109
C12N 15/00 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1217737
ABSTRACT Process for obtaining monoclonal antibodies directed against tumour antigens The present invention provides a process for obtaining monoclonal antibodies directed against tumour antigens, wherein irradiated tumour cells are injected under immunising conditions into inbred experimental animals, which cells are derived from the same inbred strain, whereafter spleen cells of the so immunised animals are isolated and, with the use of the hybridoma technique, are fused with myeloma cells, the hybridoma cells obtained are cultured and the monoclonal antibodies are obtained from the culture supernatant or from ascites fluid of those hybridoma clones which in vitro inhibit the adhesion of living tumour cells and change their morphology. The present invention also provides pharma- ceutical compositions containing the monoclonal antibodies obtained by this process.
454046
Birchmeier Walter
Vollmers Peter
Marcoux & Sher Swabey Mitchell Houle
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.v.
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