B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
B01J 2/04 (2006.01) B01D 1/18 (2006.01) B01D 11/04 (2006.01) B01F 5/02 (2006.01)
Patent
CA 2511363
Method for preparing a target substance in particulate form, by introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a solution or suspension of the target substance in a fluid vehicle (the "target solution/suspension") and (b) a compressed fluid anti-solvent for the substance, and allowing the anti-solvent to extract the vehicle from the target solution/suspension so as to form particles of the target substance, wherein the target solution/suspension enters the vessel downstream of the point of entry of the anti-solvent and at a point which lies on or close to the main axis of anti-solvent flow, and wherein the anti- solvent has a sub-sonic velocity as it enters the particle formation vessel.
L'invention concerne un procédé de préparation d'une substance cible sous forme particulaire par introduction dans un récipient de formation de particules, à travers des première et seconde entrées de fluides respectivement séparées, (a) d'une solution ou d'une suspension de la substance cible dans un véhicule fluide (la <=solution/suspension cible>=) et (b) d'un anti-solvant fluide comprimé pour la substance et qui permet à l'anti-solvant d'extraire le véhicule de la solution/suspension cible de manière à former des particules de la substance cible. La solution/suspension cible entre dans le récipient en aval du point d'entrée de l'anti-solvant et d'un point se situant sur ou à proximité de l'axe principal découlant de l'anti-solvant, cet anti-solvant possédant une vitesse subsonique lors de son entrée dans le récipient de formation de particules.
Gilbert Darren John
Kordikowski Andreas
Bereskin & Parr
Nektar Therapeutics Uk Limited
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