C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 319/06 (2006.01)
Patent
CA 2470647
The invention relates to a process for the conversion of group X in a 2-6(- substituted)-1,3-dioxane-4yl) acetic acid derivative according to formula 2 into a group OY in the presence of a phase transfer catalyst and an oxylating agent, by using as a phase transfer catalyst a quarternary phosphonium ion and by using as an oxylating agent an OY ion. X stands for a halogen and R1 and R2 and R3 are each independently a C1-4 alkygroup or R1 and R2 together with the C-atom to which they are bound form a 5- or 6-membered cycloalkyl; Y stands for RA-CO- or for RB-SO2- with RA, RB are chosen from the group of alkyl or aryl with 1-12 C-atoms.
L'invention concerne un procédé permettant de convertir un groupe X d'un dérivé d'acide 2-6(-substitué-1,3-dioxane-4yl) selon la formule 2 en un groupe OY en présence d'un catalyseur de phase de transfert et d'un agent d'oxylation, par utilisation d'un ion quaternaire de phosphonium comme catalyseur de phase de transfert et d'un ion OY comme agent d'oxylation. X représente un halogène et R<sp>1</sp>, R<sp>2</sp> et R<sp>3</sp> représentent chacun indépendamment un groupe C1-4 alkyle, ou R<sp>1</sp> et R<sp>2</sp> ensemble avec l'atome C auquel ils sont liés forment un cycloalkyle comprenant 5 ou 6 éléments; Y représente R<sp>A</sp>-CO- ou R<sp>B</sp>-SO<sb>2</sb>-, R<sp>A</sp>, R<sp>B</sp> étant choisis dans le groupe alkyle ou aryle comprenant 1-12 -atomes C.
Astrazeneca Uk Limited
Fetherstonhaugh & Co.
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