Process for preparation of 3-hydroxymethylcephems

Details Process for preparation of 3-hydroxymethylcephems Process for preparation of 3-hydroxymethylcephems

C - Chemistry, Metallurgy

07

D

260/103

C07D 501/26 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/24 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1084905

ABSTRACT OF THE DISCLOSURE The present invention relates to a novel process for preparing 3-hydroxymethyl -2-cephems by (1) reacting a 3-halomethylcephem compound with a .gamma.- or .delta.-hydroxycarboxylic acid salt and (2) reacting the .gamma. or .delta.-hydroxy esters thereby obtained with a protic acid. The 3-hydroxymethylcephems provided by the process of this invention are useful inter- mediates for the preparation of known cephalosporin anti- biotics.

274243

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