Process for preparation of 5-hydroxymethylthiazole

Details Process for preparation of 5-hydroxymethylthiazole Process for preparation of 5-hydroxymethylthiazole

C - Chemistry, Metallurgy

07

D

C07D 277/24 (2006.01) C07D 277/32 (2006.01)

Patent

CA 2204028

A process for the preparation of 5-hydroxymethylthiazole comprises reacting a compound of formula (A) with a carboxylic acid salt (optimally in the presence of a quaternary ammonium salt) and hydrolyzing the resulting ester. Subsequent dechlorination gives 5-hydroxymethylthiazole.

Procédé pour la préparation de 5-hydroxyméthylthiazole qui consiste à établir une réaction entre un composé de la formule (A) et un sel d'acide carboxylique (on réunira les conditions optimales en présence d'un sel d'ammonium quaternaire), et à hydrolyser l'ester résultant. La déchloration qui s'ensuit permet d'obtenir le 5-hydroxyméthylthiazole.

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