Process for preparation of...

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C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01)

Patent

CA 2554360

This invention relates to an improved process for the preparation of (2S,3S)-~ 2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter "compound of Formula I") and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis of the monohydrate citrate salt of the compound of Formula (la).

L'invention concerne un procédé amélioré permettant de préparer (2S,3S)- 2-benzhydryl-N-(5-tent-butyl-2-méthoxybenzyl)quinuclidine-3-amine, (ci-après "composé de la formule I") et ses sels pharmaceutiquement acceptables. Plus précisément, l'invention concerne une synthèse améliorée du sel de citrate monohydrate du composé de la formule Ia.

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