Process for preparation of a new hemin complex compound with...

Details Process for preparation of a new hemin complex compound with... Process for preparation of a new hemin complex compound with...

C - Chemistry, Metallurgy

07

F

167/127, 260/237

C07F 15/02 (2006.01) A61K 31/555 (2006.01) C07D 487/22 (2006.01) C07H 23/00 (2006.01)

Patent

CA 1242713

ABSTRACT The present invention relates to a method for the preparation of a new, physiologically active, water-soluble complex compound of hemin arginate or hemin lysinate. Accord- ing to the invention crystalline hemin and the amino acid L- arginine or L-lysine, in a molar proportion of 1:3, are allowed to react at room temperature under vigorous stirring for 10 to 15 hours in a solvent mixture of acetone and water 300:20 v/v. The hemin arginate or hemin lysinate thus formed is a powdery, stable compound suitable for use as raw material in tablets or capsules or as dry substance for preparation of injections for treatment of various types of anemia particularly anemias associated with porphyria.

473658

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