Process for preparation of an inhalation powder containing a...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/065 (2006.01) A61K 9/12 (2006.01) A61K 31/517 (2006.01) A61K 38/05 (2006.01) A61P 25/06 (2006.01) C07D 401/14 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2476711

The invention relates to salts of the active substance 1-[N2~-[3,5-dibromo-N- [[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]- L-lysyl]-4-(4-pyridinyl)-piperazine [BIBN4096] of formula (I). The invention also relates to the production of these salts, a method for producing a powder inhalant containing a salt of the active substance BIBN4096, and to the powder inhalants themselves that can be obtained by using said method.

L'invention concerne des sels du principe actif 1-[N?2´-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-pip~ridinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-pip~razine [BIBN4096] de formule (I), la production de ces sels, un proc~d~ de production d'un inhalant en poudre contenant un sel du principe actif BIBN4096, ainsi que les inhalants en poudre pouvant Útre obtenus par ce proc~d~.

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