Process for preparation of cimetidine

Details Process for preparation of cimetidine Process for preparation of cimetidine

C - Chemistry, Metallurgy

07

D

260/314

C07D 233/64 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1326490

Abstract of the Disclosure N-cyano-N'-methyl-N"-(2-(5-methyl-4- imidazolylmethylthio)ethyl)guanidine (Cimetidine), which is valuable as an agent for controlling secretion of gastric acid, is prepared in a high yield by reacting N- cyano-N'-methyl-N"-(2-(butalle-2,3-diollyl)thioethyl)- guanidine as the starting compound with an ammonium salt of a carboxylic acid and formaldehyde.

545829

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