Process for preparation of cyclic dithiodiacetamides

Details Process for preparation of cyclic dithiodiacetamides Process for preparation of cyclic dithiodiacetamides

C - Chemistry, Metallurgy

07

D

260/266.2, 260/3

C07D 295/18 (2006.01) C07D 295/185 (2006.01)

Patent

CA 1224462

ABSTRACT OF THE DISCLOSURE The present invention relates to a process for preparation of cyclic dithiodiacetamides with action inhibiting the malformation or the destruction of the red blood corpuscles due to a genetic modification of the haemoglobin or to parasites, of formula : Image in which X is a direct bond, an atom of oxygen or of sulfur, a methylene group, an ethylene group or an N-R group, where R is an atom of hydrogen or a lower alkyl group, lower (hydroxy)alkyl group, lower alkanoyl group or a phenyl group ; or their possible pharmaceu- tically acceptable salts ; said process comprising the step of reacting a dithiodiacetate or a mercaptoacetate of lower alkyl with a cyclic secondary amine, optionally oxiding the resulting compound and converting it into a pharmaceutically acceptable salt.

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