C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/10 (2006.01) A61K 39/385 (2006.01) C07H 3/06 (2006.01) C07H 9/06 (2006.01) C07H 15/04 (2006.01) C07K 1/107 (2006.01) C07K 1/113 (2006.01)
Patent
CA 2189356
Glycoconjugate antigens are prepared by preparing a hapten glycoside, especially an alpha glycoside prepared by the Fischer method with an olefinic aglycon moiety, especially one having a non-terminal double bond, ozonolyzing the hapten glycoside with an olefinic aglycon moiety having a non-terminal double bond to form a hapten-glycoside derivative, preferably without producing Germaldehyde as a by-product, removing by-products of ozonolysis, and conjugating the hapten-glycoside derivative to a carrier.
On obtient des antigènes glycoconjugués en préparant un glycoside d'haptène, notamment un alpha-glycoside préparé par le procédé Fischer, avec une fraction aglycone oléfinique, en particulier une fraction ayant une double liaison non terminale, en ozonolysant le glycoside d'haptène avec une fraction aglycone oléfinique ayant une double liaison non terminale afin d'obtenir un dérivé du glycoside d'haptène, de préférence sans former de Germaldéhyde en tant que sous-produit, en éliminant les sous-produits de l'ozonolyse et en conjuguant le dérivé du glycoside d'haptène pour former un support.
Koganty R. Rao
Wong Ting Chi
Biomira Inc.
Smart & Biggar
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