Process for preparation of n7-amidino substituted mitomycin...

Details Process for preparation of n7-amidino substituted mitomycin... Process for preparation of n7-amidino substituted mitomycin...

C - Chemistry, Metallurgy

07

D

260/279, 260/299

C07D 487/14 (2006.01)

Patent

CA 1247617

ABSTRACT OF THE DISCLOSURE There is disclosed a process for the preparation of N7-amidino substituted mitomycin C derivatives. The process comprises reacting mitomycin C or an N1a substituted derivative thereof such as porfiromycin with a chloroformi- midinium salt in a polar solvent at low temperature. This reaction is conducted in the presence of a tertiary amine. This process eliminates the need for a strong base such as NaH prior to addition of a chlorofomimidinium salt.

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