Process for preparation of optically active propoxyaniline...

Details Process for preparation of optically active propoxyaniline... Process for preparation of optically active propoxyaniline...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C07D 265/34 (2006.01) C07D 265/36 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2440411

Treatment of a racemic lactate derivative with an enzyme having an ability to hydrolyze an ester asymmetrically causes specific hydrolysis of the ester moiety of one of the optical isomers constituting the racemic lactate derivative, and use of the resulting hydrolyzate as an intermediate enables the preparation of an optically active propoxyaniline derivative in a decreased number of steps as compared with the prior art. (A)

L'invention concerne le traitement d'un dérivé de lactate racémique avec une enzyme possédant la capacité d'hydrolyser un ester de manière asymétrique, provoquant l'hydrolyse spécifique du fragment d'ester d'un des isomères optiques constituant le dérivé de lactate racémique, l'utilisation de l'hydrolysat obtenu en tant qu'intermédiaire permettant de préparer un dérivé de propoxyaniline optiquement actif en un nombre réduit d'étapes par rapport à l'état de la technique.

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