Process for preparation of perindopril and salts thereof

Details Process for preparation of perindopril and salts thereof Process for preparation of perindopril and salts thereof

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01)

Patent

CA 2517205

A process for preparation of perindopril of formula (II) and salts thereof which is simple, safe, convenient and cost-effective. The process involves reaction of compound of formula (I), wherein X is chlorine or bromine with compound of formula (VII) wherein A signifies that the six-membered ring of the bicyclic system is either saturated or unsaturated, followed by catalytic hydrogenation to give the perindopril of formula (II).

L'invention concerne un procédé de préparation de perindopril correspondant à la formule (II) et de sels de celui-ci, ce procédé étant simple, sûr, pratique et économique. Ce procédé implique la mise en réaction d'un composé correspondant à la formule (I), dans laquelle X représente chlore ou brome, avec un composé correspondant à la formule (VII), dans laquelle A signifie que le noyau à six éléments du système bicyclique est saturé ou insaturé, cette réaction étant suivie d'une hydrogénation catalytique dont le produit est le perindopril correspondant à la formule (II).

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