Process for preparation of phenethylamine derivatives

Details Process for preparation of phenethylamine derivatives Process for preparation of phenethylamine derivatives

C - Chemistry, Metallurgy

07

C

C07C 213/02 (2006.01) C07C 217/14 (2006.01) C07C 215/42 (2006.01) C07C 217/74 (2006.01)

Patent

CA 2517164

A process for the preparation of a compound of formula (I), wherein R1, and R2 are ortho or para substituents, independently selected from the group consisting of hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C7-C9 aralkoxy, C2-C7 alkanoyloxy, C1-C6 alkylmercapto, halo and trifluoromethyl; R3 is hydrogen or C1-C6 alkyl; R4 is hydrogen, C1-C6 alkyl, formyl or C2-C7 alkanoyl; n is one of the integers 0, 1, 2, 3 or 4; and the dotted line represents optional olefinic unsaturation; comprising hydrogenating a compound of formula (III), in the presence of a nickel or cobalt catalyst at a temperature of about 5~C to 25~C.

L'invention concerne un procédé de préparation d'un composé représenté par la formule (I), dans laquelle R¿1? et R¿2? représentent des substituants ortho ou para, indépendamment choisis dans le groupe constitué d'hydrogène, d'hydroxyle, alkyle C¿1?-C¿6?, alcoxy C¿1?-C¿6?, aralcoxy C¿7?-C¿9?, alcanoyloxy C¿2?-C¿7?, alkylmercapto C¿1?-C¿6?, halo et trifluorométhyle ; R¿3? représente hydrogène ou alkyle C¿1?-C¿6?; R¿4? représente hydrogène, alkyle C¿1?-C¿6?, formyle ou alkanoyle C¿2?-C¿7?; n vaut 0, 1, 2, 3 ou 4 ; et la ligne pointillée représente une insaturation oléfinique optionnelle. Ce procédé consiste à hydrogéner un composé représenté par la formule (III) en présence d'un catalyseur nickel ou cobalt à une température comprise entre environ 5 ·C et 25 ·C.

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