Process for preparation of sulfamide derivatives

Details Process for preparation of sulfamide derivatives Process for preparation of sulfamide derivatives

C - Chemistry, Metallurgy

07

C

C07C 303/34 (2006.01) C07C 307/06 (2006.01) C07D 209/14 (2006.01) C07D 211/96 (2006.01) C07D 307/81 (2006.01) C07D 333/58 (2006.01) C07D 409/12 (2006.01) C07H 1/00 (2006.01)

Patent

CA 2609185

The present invention is directed to a process for the preparation of sulphonylimine derivatives [particularly those of formula (XII)] and sulphamide derivatives [particularly those of formula (I)]. The process comprises reacting an aldehyde with a substituted or unsubstituted sulphamide, in presence of an acid or TMSCI to yield the corresponding sulphonylimine and optionally reducing or hydrogenating the sulphonylimine to yield the corresponding sulphamide derivative.

La présente invention concerne un procédé de fabrication de dérivés de sulfonylimine [notamment ceux répondant à la formule (XII)] et de dérivés de sulfamide [notamment ceux répondant à la formule (I)]. Le procédé comprend la mise en réaction d'un aldéhyde avec un sulfamide substitué ou non substitué, en présence d'un acide ou de TMSCI, de façon à obtenir la sulfonylimine correspondante, et éventuellement la réduction ou l'hydrogénation de la sulfonylimine pour obtenir le dérivé de sulfamide correspondant.

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