Process for preparing 1-{2-¬...

Details Process for preparing 1-{2-¬... Process for preparing 1-{2-¬...

C - Chemistry, Metallurgy

07

D

C07D 307/52 (2006.01) A61K 31/34 (2006.01) C07D 307/00 (2006.01) C07D 307/34 (2006.01) C07D 307/38 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2055189

Abstract The invention relates to a new process for preparing 1-{2-[(5-dimethylaminomethyl-2-furyl)-methylthio]-ethyl}- -amino-1-methylamino-2-nitroethylene of the formula (I) Image (I) (generic name: ranitidine), which comprises reacting the diketene imine derivative of formula (II) Image (II) with methylamine. The most important advantage of the invention consists in that ranitidine can be prepared in a yield of more than 90 % in an outstanding quality by a simple procedure.

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