C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/460.6
C07F 9/10 (2006.01)
Patent
CA 1068291
PROCESS FOR PREPARING 1,2-DIACYL- 3-GLYCERYLPHOSPHORYLCHOLINES Abstract A process is described for preparing a 1,2-diacyl- 3-glycerylphosphorylcholine of the formula: Image wherein R and R' are the same or different residues of a saturated or unsaturated fatty acid. According to the process a glycerylphosphorylcholine or monoacyl derivative thereof or the salt thereof is acylated with 1-acylimidazole or 4-acyl- 3-phenyl-1,2,4-oxadiazol-5-one in the presence of an alkali salt of a nitorgen-containing 5-membered heterocyclic compound or sodium oxide as a catalyst. The product is well known as "lecithin" and is widely used in the medical and pharmaceutical fields.
244535
Kashima Kenichi
Kudoh Haruyoshi
Miyamoto Akira
Nakajima Tadashi
Soda Yasuji
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