Process for preparing 1,5-diaryl-3-substituted pyrazoles

Details Process for preparing 1,5-diaryl-3-substituted pyrazoles Process for preparing 1,5-diaryl-3-substituted pyrazoles

C - Chemistry, Metallurgy

07

D

C07D 231/12 (2006.01)

Patent

CA 2346142

A process for making a compound of formula (I) wherein the substituents are as described in the specification com-prising reacting a ketone of formula (II) with succinic anhydride and an alkoxide base to form a compound of formula (III) which is reacted with a compound of formula (IV) to form a compound of formula (V) and reacting with an alcohol to form the corresponding ester of formula (VI) and reacting the ester with N-methylhydroxylamine.

Ce procédé de préparation d'un composé correspondant à la formule (I), dans lequel les substituants sont tels que décrits dans la spécification, consiste à faire réagir une cétone possédant la formule (II) avec de l'anhydride succinique et une base alcoxyde, afin de former un composé possédant la formule (III), que l'on fait réagir avec un composé correspondant à la formule (IV) de manière à obtenir un composé possédant la formule (V), puis à faire réagir ce dernier composé avec un alcool, de manière à former un ester correspondant à la formule (VI) et enfin à faire réagir cet ester avec une <i>N</i>-méthylhydroxylamine.

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