Process for preparing 1,5-diaryl-3-substituted pyrazoles

Details Process for preparing 1,5-diaryl-3-substituted pyrazoles Process for preparing 1,5-diaryl-3-substituted pyrazoles

C - Chemistry, Metallurgy

07

C

C07C 51/083 (2006.01) C07C 59/76 (2006.01)

Patent

CA 2636755

A process for making a compound of formula (I) wherein the substituents are as described in the specification comprising reacting a ketone of formula (II) with succinic anhydride and an alkoxide base to form a compound of formula (III) which is reacted with a compound of formula (IV) to form a compound of formula (V) and reacting with an alcohol to form the corresponding ester of formula (VI) and reacting the ester with N-methylhydroxylamine. (see formula III, V and VI)

Procédé pour fabriquer un composé de formule (I), où les substituants sont tels que décrits dans le mémoire descriptif, procédé consistant à faire réagir une cétone de formule (II) avec un anhydride succinique et avec une base alkoxyde afin d'obtenir un composé de formule (III), que l'on fait réagir avec un composé de formule (IV) pour former un composé de formule (V) et en le faisant réagir avec un alcool afin d'obtenir l'ester correspondant de formule (VI), puis en faisant réagir l'ester avec de la N-méthylhydroxylamine (voir les formules III, V et VI).

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