Process for preparing 1-(p-tert-butylphenyl)-4-...

Details Process for preparing 1-(p-tert-butylphenyl)-4-... Process for preparing 1-(p-tert-butylphenyl)-4-...

C - Chemistry, Metallurgy

07

D

260/292.2

C07D 211/22 (2006.01)

Patent

CA 1309101

68217-182 ABSTRACT The present invention relates to a process for preparing terfenadine which is based on the reduction of terfena- done by an alkali metal borohydride, said process being characterized in that the reaction is carried out in a two-phase system in the presence of a phase transfer catalyst. The process of the present invention permits obtaining terfenadine in each of the two substantially pure polymorphic forms directly.

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