Process for preparing 1-substituted 5-acylimidazole compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 233/64 (2006.01)

Patent

CA 2619731

Disclosed is a commercially suitable method for producing a 1-substituted-5- acylimidazole compound. A 1-substituted-5-acylimidazole compound is produced with a high position selectivity by reacting an N-substituted amidine compound or a salt thereof with a ketone compound in the presence of a base.

La présente invention concerne un procédé approprié sur le plan commercial de production d~un composé 5-acylimidazole substitué en position 1. Un composé 5-acylimidazole substitué en position 1 est produit avec une sélectivité de position élevée en faisant réagir un composé amidine N-substitué ou un sel de celui-ci avec un composé cétone en présence d'une base.

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