Process for preparing 1-tert.-butylamino-3-(2,5-...

Details Process for preparing 1-tert.-butylamino-3-(2,5-... Process for preparing 1-tert.-butylamino-3-(2,5-...

A - Human Necessities

61

K

260/604.2, 260/6

A61K 31/135 (2006.01) A61K 31/13 (2006.01) A61K 31/055 (2006.01)

Patent

CA 1091254

ABSTRACT OF THE DISCLOSURE The invention relates to a process for the preparation of racemic and optically acbive 1-tert.-butylamino-3- (2,5-dichlorophenoxy)-2-propanol and its acid addition salts wherein racemic or optically active 1,2-epoxy-3-(2,5-di- chlorophenoxy)-propane is reacted in an apolar medium in the presence of tin(IV)-chloride with an N-tert.-butyl- formimidic acld alkyl ester, followed by adding to the reaction mixture an alkanol containing hydrochloric acid. The process affords in a simple and rapid way and in high yields a product which is directly usable for therapeutic purposes.

272912

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