C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/28 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2685047
The present invention relates to a process for preparing 2-(2-pyridylmethyl)sulphinyl-1H-benzimidazoles that are proton pump inhibitors, using as intermediates 2-benzimidazolylsulphinic acid derivatives. The present invention also relates to saidintermediate compounds, their use and a process for the preparation thereof. These novel intermediate compounds are 2-benzimidazolylsulphinicacid esters that are obtained from their corresponding alkaline salts, which are in turn obtained by oxidation of substituted 2-mercaptobenzimidazoles. The intermediate compounds of the invention are converted into 2-(2- pyridylmethyl)sulphinyl-1H-benzimidazoles by reaction with substituted 2- methylpyridines.
L'invention porte sur un procédé de préparation de 2-(2-pyridylméthyl) sulphinyl-1H-benzimidazoles, inhibiteurs de la pompe à protons, utilisant comme intermédiaires des dérivées de l'acide 2-benzimidazolylsulphinique. L'invention porte également sur lesdits intermédiaires, leur utilisation et leur procédé de préparation. Ces nouveaux composés intermédiaires sont des esters de l'acide 2-benzimidazolylsulphinique, obtenus de leur sels alcalins correspondants, obtenus à leur tour par oxydation de 2-mercaptobenzimidazoles. Lesdits intermédiaires sont convertis en 2-(2- pyridylméthyl)sulphinyl-1H-benzimidazoles par réaction avec des 2- méthylpyridines substituées.
Molina Ponce Andres
Palomo Nicolau Francisco Eugenio
Pastor Del Castillo Alfredo
Chemo Iberica S.a.
Robic
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