C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 317/12 (2006.01) C07D 317/24 (2006.01)
Patent
CA 2671856
The present invention provides a novel process for the preparation of 3,5-di-O- acyl-2-fluoro-2-C-methyl-D-ribono-g-lactone derivatives of formula (2) which are key intermediates in the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-.beta.-D-ribofuranosyl)cytosine (formula (1)) a compound that possesses potent and selective anti-hepatitis C virus activity.
L'invention concerne un nouveau procédé de préparation de dérivés de 3,5-di-O- acyl-2-fluoro-2-C-méthyl-D-ribono-g-lactone de formule indiquée ci-après, lesquels sont des intermédiaires clés dans la préparation de la 1-(2-déoxy-2-fluoro-2-C-méthyl- .beta.-D-ribofuranosyl)cytosine, qui est un composé qui possède une activité virale puissante et sélective anti-hépatite C..
Cedilote Miall
Cleary Thomas P.
Iding Hans
Zhang Pingsheng
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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