C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 51/353 (2006.01) C07C 51/60 (2006.01) C07C 61/08 (2006.01) C07C 319/06 (2006.01) C07C 319/20 (2006.01) C07C 321/24 (2006.01) C07C 321/28 (2006.01) C07C 327/30 (2006.01)
Patent
CA 2672505
The present invention relates to a process for the preparation of 1 -(2-cthyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of, pharmaceutical active compounds, comprising reacting cyclohexanecarboxylic acid derivative of formula (II) wherein Y is an alkali metal, with an alkylating agent, in the presence of a secondary amine and (C1-C6)alkyllithium, (C3-C6)cycloalkyllithium or phenyllithium.
La présente invention concerne un procédé de préparation de l'acide 1-(2-éthyl-butyl)-cyclohexane carboxylique, lequel est utilisable en tant qu'intermédiaire dans la préparation de composés pharmaceutiquement actifs. Selon l'invention, ledit procédé comprend la réaction d'un dérivé de l'acide cyclohexane carboxylique de formule (II), dans laquelle Y est un métal alcalin, avec un agent alkylant en présence d'une amine secondaire et de (C1-C6)alkyl-lithium, de (C3-C6)cycloalkyl-lithium ou de phényl-lithium.
Hoffmann Ursula
Lohri Bruno
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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