Process for preparing...

Details Process for preparing... Process for preparing...

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01)

Patent

CA 2051985

PROCESS FOR PREPARING 1-[(2S)-3-MERCAPTO-METHYL-1- OXOPROPYL]-L-PROLINE Abstract The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L- proline (captopril) of formula (I). Image (II) which comprises hydrogenating 1-[(2S)-2-methyl-1-oxo-3- rhodanidopropyl]-L-proline of formula (II) Image (II) in an inert solvent, in the presence of a catalyst, at a temperature of 50 to 120 °C under a pressure of 105 to 107 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido- propionic acid of formula (III). -2- Image (III) The process of the invention renders possible to produce the compound of formula (I) in a simple way with high purity and good overall yields.

Affiliated with

Also associated with

Rating

Process for preparing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2030659