Process for preparing...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 521/00 (2006.01) A61K 31/4178 (2006.01) A61P 1/08 (2006.01) C07D 209/88 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2483566

A process for preparing ondansetron by transamination of an ondansetron structural analog that can be readily prepared conveniently by a Mannich reaction is provided. The process represents an improvement upon known procedures for making ondansetron by transamination because of its rapid rate, selectivity and the ease with which the product can be isolated from the reaction mixture.

L'invention concerne une méthode de préparation d'ondansetron, par transamination d'un analogue structural d'ondansetron pouvant être préparé facilement et sans inconvénient par réaction de Mannich. La méthode de l'invention représente une amélioration par rapport aux procédés connus de production d'ondansetron par transamination, du fait de la vitesse, de la sélectivité et de la facilité avec lesquelles le produit peut être isolé du mélange réactionnel.

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