Process for preparing 2-acylglycerides or 1,2-diacyl...

C - Chemistry – Metallurgy – 12 – P

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C12P 7/64 (2006.01) C07C 69/003 (2006.01) C11C 3/08 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2079888

A process for the selective hydrolysis of triglycerides to 2-acyl glycerides is disclosed. This process uses a primary lower alkyl alcohol selected from the group consisting of methanol, the primary butanols and the primary pentanols and 2-butanol, an aqueous buffer system and a 1,3-lipase. The 2-acyl monoglycerides can be used to make stereospecific 1,2-diacyl glycerides or 2,3-diacyl glycerides through esterification with acid anhydrides and 1,3-lipase catalysis. Stereospecific 1,2,3-triglycerides can be made from these materials by standard esterification reactions under conditions which control rearrangement.

L'invention porte sur l'hydrolyse sélective de triglycérides en 2-acylglycérides. Le procédé utilise un alcool primaire de type alkyle inférieur, soit le méthanol, un butanol primaire, un pentanol primaire ou le butan-2-ol, un système tampon aqueux et une 1,3-lipase. Les 2-acylmonoglycérides peuvent servir à obtenir des 1,2-diacylglycérides stéréospécifiques ou non par estérification avec des anhydrides d'acide et la 1,3-lipase comme système catalytique. Les 1,2,3-triglycérides stéréospécifiques peuvent être obtenus à partir de ces produits par des réactions d'estérification normale, dans des conditions permettant de contrôler le réarrangement moléculaire.

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