C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/56 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) C07D 239/00 (2006.01) C07D 241/00 (2006.01) C07D 277/00 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2555291
The invention relates to processes for preparing compounds having the formula (I) and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R2, R3, R4, and R5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.
L'invention concerne des procédés destinés à la préparation de composés représentés par la formule générale (1) et de leurs formes cristallines, Ar désignant un aryle ou un hétéroaryle, L désignant une liaison alkylène facultative et R2, R3, R4 et R5 désignant des éléments décrits dans la description de la présente demande. Ces composés sont utiles comme inhibiteurs de kinases et, plus particulièrement, comme inhibiteurs de la protéine tyrosine kinase et de la protéine p38.
Chen Bang-Chi
Chidambaram Ramakrishnan
Dimarco John D.
Droghini Roberto
Galella Michael
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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