Process for preparing 2.beta.-substituted-methylpenicillin...

Details Process for preparing 2.beta.-substituted-methylpenicillin... Process for preparing 2.beta.-substituted-methylpenicillin...

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/87 (2006.01) C07D 499/00 (2006.01) C07D 521/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1339124

A process for preparing a 2.beta.-substituted-methylpenicillin compound of the formula (See Fig. I) wherein -N Y is an optionally substituted heterocyclic group containing 2 to 4 nitrogen atoms as the hetero atom in the ring structure, and R1 is a penicillin carboxyl protecting group, the process comprising reacting an azetidinonedisulfide compound of the formula (See Fig. III) wherein R1 is as defined above and R is a substituted or unsubstituted heterocyclic group with a nitrogen-containing heterocyclic compound of the formula (See Fig. IV) wherein (See Fig. V) is as defined above in the presence of a metal compound.

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