Process for preparing 2.beta.-substituted-methylpenicillin...

Details Process for preparing 2.beta.-substituted-methylpenicillin... Process for preparing 2.beta.-substituted-methylpenicillin...

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1294953

Abstract of the disclosure: Disclosed is a process for preparing 2.beta.- substituted-methylpenicillin derivative of the formula Image (I) wherein R is H or carboxyl protecting group, R1 is H or halo, R2 is H, lower alkyl, lower alkoxy, halogen, azido, lower alkylthio, phthalimide or a group -NHR3 (wherein R3 is H or acyl), and Image is an optionally substituted monocyclic or bicyclic heterocyclic group having 1 to 4 nitrogen atoms in the ring structure, the process comprising reacting a compound of the formula Image (II) wherein X is Cl or Br, and R, R1 and R2 are as defined above with a heterocyclic compound of the formula Image (III) wherein Image is as defined above.

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