Process for preparing 2-substituted imidazoles

Details Process for preparing 2-substituted imidazoles Process for preparing 2-substituted imidazoles

C - Chemistry, Metallurgy

07

D

260/314

C07D 233/58 (2006.01)

Patent

CA 1283115

Abstract A process for preparing 2-unsubstituted imid- azoles which comprises reacting an ?-hydroxycarbonyl compound with a formamide in such amounts as to make the molar ratio of said formamide to said hydroxycarbonyl compound not more than 2 at a reaction temperature of 100-170°C in an atmosphere of ammonia gas. According to this process, 2-unsubstituted imidazoles may be obtained in very high yields. In addition, because no great excess of formamide is used in carrying out the reaction, an effect of not requiring the recovery operation incident to decomposition of formamide is obtained as well. And by removing formic acid formed as a by-product by the reac- tion, a reactor and separation equipment such as a dis- tillation column are not corroded, and imidazoles of a high purity can be obtained.

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