Process for preparing 21-desoxyprednisolone 17-esters

Details Process for preparing 21-desoxyprednisolone 17-esters Process for preparing 21-desoxyprednisolone 17-esters

C - Chemistry, Metallurgy

07

J

260/86

C07J 7/00 (2006.01) C07J 5/00 (2006.01) C07J 21/00 (2006.01) C07J 31/00 (2006.01)

Patent

CA 2027627

A process for preparing 21-desoxyprednisolone 17-esters of formula (IV) is disclosed. Image The process comprises reacting a prednisolone 17.alpha.,21-cyclic orthoester With an acid in a 40-60% lower alcohol solution to produce a prednisolone 17-ester, sulfonylating the prednisolone 17-ester into a prednisolone 17-ester 21-sulfonate, and reacting the sulfonate with an alkali metal iodide in methyl ethyl ketone in the presence of a lower fatty acid to produce the compound of formula (IV). The process ensures economical industrial production of high purity 21-desoxyprednisolone 17-esters, an excellent local anti-inflammatory medicine, in a high yield by simple procedures.

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