Process for preparing 3-alkenylidene-1,1-bisphosphonates

Details Process for preparing 3-alkenylidene-1,1-bisphosphonates Process for preparing 3-alkenylidene-1,1-bisphosphonates

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2067836

HX51 Abstract PROCESS FOR PREPARING 3-ALKENYLIDENE-1,1-BISPHOSPHONATES A process is provided for preparing a 3-alkenylidene-1,1-bisphosphonate which is an inter- mediate for preparing an inhibitor of the enzyme squalene synthetase and therefore useful as an inhibitor of cholesterol biosynthesis, or which bisphosphonate itself is useful as an inhibitor of cholesterol biosynthesis. The process involves the palladium catalyzed coupling of an allylic ester with a tetraester of a methylenebisphosphonate to form a 3-alkenylidene-1,1-bisphosphonate containing an alkene moiety located ?, .delta. to the phosphonates.

Affiliated with

Also associated with

Rating

Process for preparing 3-alkenylidene-1,1-bisphosphonates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 3-alkenylidene-1,1-bisphosphonates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 3-alkenylidene-1,1-bisphosphonates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1799158