C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/335.3
C07D 205/04 (2006.01)
Patent
CA 1221975
PROCESS FOR PREPARING 3-PHENOXY-1- AZETIDINES AND CARBOXAMIDE DERIVATIVES ABSTRACT An improved process is disclosed for preparing 3-phenoxyazetidines which utilizes a phase transfer catalyst to add the phenoxy group to azetidine blocked in the l-position by a diphenylmethane group and utilizes a stabilizing tertiary amine base to prevent dimerization during hydroqenolysis to remove the blocking group. The crude product containing diphenylmethane may be used without purification to prepare 3-phenoxy-1- azetidinecarboxamides.
458081
Lo Young S.
Mays Richard P.
Smart & Biggar
Wyeth
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