C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/335.5
C07D 205/08 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1256443
Abstract of the disclosure A process for preparing 4-acetoxy-3- hydroxyethylazetidin-2-one derivative having the general formula (II): Image (II) wherein R1 is a protective group for hydroxy group, which comprises reacting the .beta.-lactam compound having the general formula (I): Image (I) wherein R1 is above, R2, R3 and R4 are a lower alkyl group of C1 to C4, phenyl group or aralkyl group and R is a protective group fox N, with acetic anhydride in the organic solvent in the presence of base and then removing the protective group for N. 4-Acetoxy-3-hydroxyethylazetidin-2-one derivatives are the useful intermediates for preparing carbapenem .beta.-lactam antibiotics such as thienamycin and penem .beta.-lactam antibiotics.
485100
Kan Kazunori
Miyama Akimasa
Ohashi Takehisa
Sada Isao
Watanabe Kiyoshi
Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
Osler Hoskin & Harcourt Llp
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