Process for preparing 4'-haloanthracycline glycosides

Details Process for preparing 4'-haloanthracycline glycosides Process for preparing 4'-haloanthracycline glycosides

C - Chemistry, Metallurgy

07

H

260/208.2

C07H 15/252 (2006.01)

Patent

CA 1250833

\ ABSTRACT OF THE DISCLOSURE A process for preparing 4'-halo-anthracycline glycosides having general formula A : Image A in which X=H or OH, R1=H, OH or OCH3, R2=Br, Cl or F useful as antitumour agents. Those in which X=H may be prepared by an exchange reaction between a 4'-epi-4'-O- trifluoromethanesulphonyl-N-protected-daunorubicin (or a corresponding 4-demethyl or 4-demethoxy derivative) and (C4H9)4NCl, (C4H9)4NBr or C5F. Those in which X=OH are prepared from those in which X=H by bromination and reaction with aqueous sodium formate.

460796

Affiliated with

Also associated with

Rating

Process for preparing 4'-haloanthracycline glycosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 4'-haloanthracycline glycosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 4'-haloanthracycline glycosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1331670